3Ps – Plastic-Antibodies, Plasmonics and Photovoltaic-Cells: on-site screening of cancer biomarkers made possible

O projeto 3 Ps – Plastic-Antibodies, Plasmonics and Photovoltaic-Cells: on-site screening of cancer biomarkers made possible recebeu cerca de 1 milhão de euros através do programa European Research Council – Starting Grant.

Dado que as doenças cancerígenas continuam a ser uma grande preocupação em termos de saúde pública, este projeto apresenta um novo conceito de deteção, diagnóstico e monitorização do cancro, efetuado no local de prestação de cuidados. O instrumento em desenvolvimento combinará a seletividade dos anticorpos como material sensor com a autonomia de operação de uma célula fotovoltaica, equipada com estruturas plasmónicas para aumentar a eficiência celular. O instrumento será facilmente operável e aplicável às formas mais frequentes de doenças cancerígenas.

O projeto tem uma duração de 60 meses, decorrendo nas instalações do Instituto Superior de Engenharia do Porto, sob a liderança do CINTESIS.ISEP.

This project presents a new concept for the detection, diagnosis and monitoring of cancer biomarker patterns in point-of-care. The device under development will make use of the selectivity of the plastic antibodies as sensing materials and the interference they will play on the normal operation of a photovoltaic cell.

Plastic antibodies will be designed by surface imprinting procedures. Self-assembled monolayer and molecular imprinting techniques will be merged in this process because they allow the self-assembly of nanostructured materials on a “bottom-up” nanofabrication approach. A dye-sensitized solar cell will be used as photovoltaic cell. It includes a liquid interface in the cell circuit, which allows the introduction of the sample (also in liquid phase) without disturbing the normal cell operation. Furthermore, it works well with rather low cost materials and requires mild and easy processing conditions. The cell will be equipped with plasmonic structures to enhance light absorption and cell efficiency.

The device under development will be easily operated by any clinician or patient. It will require ambient light and a regular multimeter. Eye detection will be also tried out.

European Research Council – Starting Grant

998 584,00 €

998 584,00 €

Goreti Sales (PI)

http://cordis.europa.eu/project/rcn/106352_en.html

Última atualização: 31 de dezembro de 2017